The Diabetes and Obesity Center of Excellence at the University of Washington

We work together for a future free of disease related to diabetes and obesity

Learn About Our Programs

The Center draws upon the expertise of a wide range of investigators with complementary interests in diabetes, obesity, inflammation, lipid metabolism and atherosclerosis. Members of the Center’s faculty conduct both basic research to clarify the mechanisms causing diabetes and obesity and their consequences, and translational research to transform their research findings into clinical solutions.

Disease Information

Two-thirds of the adult U.S. population is overweight and one-half of those individuals – one-third of the adult population – are obese. The prevalence of type 2 diabetes (formerly known as “adult-onset”) has also increased markedly in recent decades not only among adults, but in children as well. Although type 1 diabetes is less common, it is a potentially devastating disorder affecting both children and adults and, while treatments for both types of diabetes exist, neither is curable and effective treatments for obesity have yet to be developed.

How To Get Involved

Much of the good we accomplish is made possible by private support: by people and organizations underwriting leading-edge research and providing funding to train promising fellows. With your help, the DOCE is improving lives throughout the Northwest and around the world.

Our Research Programs

Latest News and Events

DOCE Director Michael Schwartz, MD, Featured in ASCI Interview

Dr. Michael Schwartz is featured in an interview by the American Society for Clinical Investigation (ASCI), published on September 10, 2014.

DOCE Researcher Joshua Thaler, MD, PhD, Receives NIH R03

Dr. Joshua Thaler has been awarded an NIH R03 for his project entitled “Glial-neuronal metabolic coupling in obesity”.

DOCE Researcher Joshua Thaler, MD, PhD, Receives ADA Pathway Award

Dr. Joshua Thaler is one of 5 recipients awarded a Pathway to Stop Diabetes Accelerator Award from the American Diabetes Association. This 5-year, $1.625 million grant entitled ” Modulating glial-neuronal interactions to treat obesity and diabetes” explores the possibility that glial cells (the brain’s damage response cells) in the hypothalamus area of the brain play an important part in the process of becoming obese and developing diabetes.

DOCE Director Michael Schwartz, MD, Receives NIH R01

Dr. Michael Schwartz has been awarded a 4-year NIH R01 for his project ” Novel Brain Mechanisms Controlling Glucose Homeostasis”. This project is based upon recently published evidence from the Schwartz Laboratory that the brain can rapidly, potently and selectively increase insulin-independent glucose lowering.

DOCE researchers published in Cell Reports

DOCE Associate Director Karin Bornfeldt, PhD is senior author of an article published in the April issue of Cell Reports (Cell Press).

DOCE Director Dr. Michael Schwartz Awarded 2014 Hammond Memorial Lecture

DOCE Director Michael Schwartz, MD, has been selected to give the 7th Annual Levi J. Hammond Distinguished Memorial Lecture. This annual lecture was held at the University of Pennsylvania on May  13, 2014.…

DOCE Researchers published in Nature Reviews Neuroscience

DOCE Director Michael Schwartz, MD, is senior author on a review article published in the May issue of  Nature Review Neuroscience. The article entitled “Neurobiology of food intake in health and disease…” highlights how the interplay between homeostatic and emergency feeding circuits influences the biologically defended level of body weight under physiological and pathophysiological conditions.

DOCE Associate Director Karin Bornfeldt, PhD, Awarded 2014 Edwin Bierman Lectureship

Dr. Karin Bornfeldt, PhD, has been awarded the 2014 Edwin Bierman Lectureship. The lecture will be delivered at the American Diabetes Association’s Annual Sessions in San Francisco, June 16th.

DOCE Director Michael Schwartz, MD, Receives NIH R01

Dr. Michael Schwartz has been awarded a 5-year NIH R01 for his project “Novel Anti-Diabetic Actions of Hypothalamic FGF19-FGFR1 Signaling

DOCE Associate Director Karin Bornfeldt, PhD, Awarded 2013 Russell Ross Memorial Lectureship in Vascular Biology

Dr. Karin Bornfeldt, PhD, has been awarded the 2013 Russell Ross Memorial Lectureship in Vascular Biology. The lecture was delivered at the American Heart Association’s Annual Sessions in Dallas on November 19th.